Diftavax
Diftavax (adsorbed diphtheria [low dose] and tetanus vaccine for adults
and adolescents) was discontinued by sanofi pasteur MSD in January 2006.
Diftavax is now unavailable and adsorbed diphtheria [low dose], tetanus
and inactivated poliomyelitis vaccine (Revaxis; sanofi pasteur MSD) is
now recommended by the Department of Health.
Dopamine agonists
The European Pharmacovigilance Working Party has reviewed the available
data on the following dopamine agonists: levodopa (in combination with
carbidopa, benserazide or entacapone),
a-dihydroergocryptine, apomorphine, bromocriptine, cabergoline, lisuride,
pergolide, piribedil, pramipexole, quinagolide, rotigotine and ropinirole.
Evidence from spontaneous reports and scientific literature suggests
that
pathological gambling and increased libido, including hypersexuality,
may be class effects of dopamine agonists, especially at high doses,
generally reversible upon reduction of the dose or treatment discontinuation.
The Medicines and Healthcare products Regulatory Agency has requested that marketing authorisation holders for all dopamine agonists for all indications, including restless legs syndrome, endocrine disorders and Parkinson’s disease, update their summaries of product characteristics accordingly.
